Usage of 11 PMXT 20 mg | DrugInfo.In

Usage of 11 PMXT 20 mg

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Tadalafil is an oral drug that is used for treating impotence the inability to attain or maintain a penile erection andbenign prostatic hyperplasia BPH It is in a class of drugs called phosphodiesterase inhibitors that also includes sildenafil Viagra andvardenafil Levitra Erection of the penis is caused by the filling of the penis with blood Filling occurs because the blood vessels that bring blood to the penis increase in size and deliver more blood to the penis and at the same time the blood vessels that take blood away from the penis decrease in size and remove less blood from the penis Sexual stimulation that leads to an erection causes the production and release of nitric oxide in the penis The nitric oxide causes an enzyme guanylate cyclase to produce cyclic guanosine monophosphate cGMP It is cGMP that is primarily responsible for increasing and decreasing the size of blood vessels carrying blood to and from the penis respectively and causing an erection When the cGMP is destroyed by another enzyme phosphodiesterase5 the blood vessels return to their normal size blood leaves the penis and the erection ends Tadalafil prevents phosphodiesterase5 from destroying cGMP so that cGMP stays around longer The persistence of cGMP leads to a more prolonged engorgement of the penis with bloodThe mechanism whereby tadalafil improves the symtoms of BPH is not clear but phosphodiesterase5 also is present in the muscles of the bladder and the prostate and it has been suggested that the relaxation of these muscles may make the passage of urine less difficult for example by reducing the pressure in the muscle surrounding the opening to the urethra that controls the flow of urine from the bladder Tadalafil was approved by the FDA in November 2003

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