Precautions before taking 3 D 30 gm

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Diclofenac like other NSAIDs is associated with several suspected or probable interactions that affect the action of other drugs Some examples are discussed below Diclofenac may increase the blood levels of lithium Eskalith by reducing the excretion of lithium by the kidneys Increased levels of lithium may lead to lithium toxicity Diclofenac may reduce the blood pressure lowering effects of blood pressure medications This may occur because prostaglandins play a role in the regulation of blood pressure When diclofenac is used in combination with aminoglycoside antibiotics for example gentamicin Garamycin the blood levels of the aminoglycoside may increase presumably because the elimination of aminoglycosides from the body is reduced This may lead to more aminoglycosiderelated side effects Individuals taking oral blood thinners or anticoagulants for examplewarfarin Coumadin should avoid diclofenac because diclofenac also thins the blood and excessive blood thinning may lead to bleeding Combining NSAIDs with methotrexate Rheumatrex Trexall may reduce the elimination of methotrexate from the body and result in increased side effects from methotrexate